Which statement best describes CCP antibodies' target?

Which statement best describes CCP antibodies' target?

• A. They target DNA
• B. They target citrullinated peptides that reflect altered protein shapes
• C. They target lipids
• D. They target RNA

Answer: (B)

CCP antibodies are directed against citrullinated peptides. Citrullination is a post-translational modification that converts arginine residues to citrulline, altering protein shape and charge. This modification creates new epitopes that the immune system can recognize, leading to autoantibody production against these citrullinated epitopes. The test uses cyclic citrullinated peptide antigens to detect these antibodies, which is why this option best describes their target. They do not bind DNA, lipids, or RNA.

CCP antibodies are directed against citrullinated peptides. Citrullination is a post-translational modification that converts arginine residues to citrulline, altering protein shape and charge. This modification creates new epitopes that the immune system can recognize, leading to autoantibody production against these citrullinated epitopes. The test uses cyclic citrullinated peptide antigens to detect these antibodies, which is why this option best describes their target. They do not bind DNA, lipids, or RNA.