Which immunoglobulin class is involved in the rheumatoid factor reaction?

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Prepare for the Clinical Chemistry II Test with multiple choice questions and detailed explanations. Enhance your medical knowledge and ready yourself for success!

Multiple Choice

Which immunoglobulin class is involved in the rheumatoid factor reaction?

Explanation:
Rheumatoid factor is an autoantibody directed against the Fc portion of IgG, and it is most commonly of the IgM class. This IgM anti-IgG binds circulating IgG to form immune complexes, which can activate complement and contribute to inflammatory joints in rheumatoid arthritis. While RF activity can be seen with other isotypes in some contexts, the classic and most clinically highlighted association is IgM.

Rheumatoid factor is an autoantibody directed against the Fc portion of IgG, and it is most commonly of the IgM class. This IgM anti-IgG binds circulating IgG to form immune complexes, which can activate complement and contribute to inflammatory joints in rheumatoid arthritis. While RF activity can be seen with other isotypes in some contexts, the classic and most clinically highlighted association is IgM.

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