Fibrinogen is involved in which physiological process?

Fibrinogen is involved in which physiological process?

• A. Coagulation
• B. Oxygen transport
• C. Glucose metabolism
• D. Immune response

Answer: (A)

Fibrinogen’s main role is in coagulation. It is a soluble plasma protein made by the liver that participates in the formation of a stable blood clot. During coagulation, thrombin cleaves fibrinogen to form fibrin monomers, which then polymerize into a fibrin mesh that stabilizes the platelet plug. Platelets also bind fibrinogen through the GPIIb/IIIa receptor, promoting platelet aggregation as part of hemostasis, and factor XIIIa crosslinks the fibrin strands to strengthen the clot. While fibrinogen levels can rise in inflammatory states as an acute-phase reactant, its primary function relevant to physiology is facilitating clot formation to stop bleeding. Oxygen transport is carried out by hemoglobin, glucose metabolism by various metabolic pathways and enzymes, and the immune response by immune cells and antibodies, not by fibrinogen’s main action.

Fibrinogen’s main role is in coagulation. It is a soluble plasma protein made by the liver that participates in the formation of a stable blood clot. During coagulation, thrombin cleaves fibrinogen to form fibrin monomers, which then polymerize into a fibrin mesh that stabilizes the platelet plug. Platelets also bind fibrinogen through the GPIIb/IIIa receptor, promoting platelet aggregation as part of hemostasis, and factor XIIIa crosslinks the fibrin strands to strengthen the clot. While fibrinogen levels can rise in inflammatory states as an acute-phase reactant, its primary function relevant to physiology is facilitating clot formation to stop bleeding. Oxygen transport is carried out by hemoglobin, glucose metabolism by various metabolic pathways and enzymes, and the immune response by immune cells and antibodies, not by fibrinogen’s main action.