Abnormal IgG production in the joint capsules leads to what immediate consequence?

Abnormal IgG production in the joint capsules leads to what immediate consequence?

• A. IgG becomes an antigen to IgMs, causing IgMs to react
• B. IgM production increases due to IgG deficiency
• C. IgMs react, causing local tissue damage
• D. IgG becomes an antigen to IgMs so IgMs do not react

Answer: (C)

When abnormal IgG is present in the joint, IgM autoantibodies known as rheumatoid factors can recognize and bind to it. This binding forms immune complexes in the synovium. Those immune complexes activate the classical complement pathway and recruit inflammatory cells, releasing mediators that cause local tissue inflammation and damage to the joint structures. So the immediate consequence is IgMs reacting with IgG to form immune complexes that drive local tissue injury.

When abnormal IgG is present in the joint, IgM autoantibodies known as rheumatoid factors can recognize and bind to it. This binding forms immune complexes in the synovium. Those immune complexes activate the classical complement pathway and recruit inflammatory cells, releasing mediators that cause local tissue inflammation and damage to the joint structures. So the immediate consequence is IgMs reacting with IgG to form immune complexes that drive local tissue injury.